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Table 2 Number of drug targets present in isolated components in the full and reliable subsets

From: Effects of protein interaction data integration, representation and reliability on the use of network properties for drug target prediction

Network # Connected components # Proteins in disconnected components # Drug targets in disconnected components
Full PIN 140 324 7
B subset 139 354 12
Non-predicted subset 164 376 12
MI score - IntAct 75 207 18
LTP subset 188 428 27
MI score - PSICQUIC 138 372 41
  1. The full PIN contains 7 drug targets that are disconnected from the main component. This number increases as interactions are removed to generate subsets of the data that are potentially more reliable; i.e., more drug targets become disconnected from the largest component of the network.