Effects of protein interaction data integration, representation and reliability on the use of network properties for drug target prediction

Table 2 Number of drug targets present in isolated components in the full and reliable subsets

Network	# Connected components	# Proteins in disconnected components	# Drug targets in disconnected components
Full PIN	140	324	7
B subset	139	354	12
Non-predicted subset	164	376	12
MI score - IntAct	75	207	18
LTP subset	188	428	27
MI score - PSICQUIC	138	372	41

The full PIN contains 7 drug targets that are disconnected from the main component. This number increases as interactions are removed to generate subsets of the data that are potentially more reliable; i.e., more drug targets become disconnected from the largest component of the network.

ISSN: 1471-2105