Figure 2

Comparison of correlation and mutual information based co-expression measures in 8 empirical data sets. Absolute value of bicor versus A^{MI,UniversalVersion 2}for all probe pairs in each data set. The Spearman correlation and corresponding p-value between the two measures are shown at the top. The two measures show different levels of monotonic relationships in data sets. The red curve predicts A^{MI,UniversalVersion 2}from bicor based on Eq. 18. The blue circle highlights the probe pair with the highest A^{MI,UniversalVersion 2}z-score among those with insignificant bicor z-scores (less than 1. 9 ); the red circle highlights the probe pair with the highest bicor z-score among those with insignificant A^{MI,UniversalVersion 2}z-scores (less than 1. 9 ).