Figure 6

Drug response data, empirical Bayes analysis. Parameters controlling source of prior information and prior strength (m and λ respectively) were set objectively using the data. Log marginal likelihood (calculated exactly up to a constant) is plotted against λ for m = 1 (number of pathways prior) and m = 2 (intra-pathway distance prior). Parameters were set to the values with maximal marginal likelihood: m = 2 and λ = 5.