Figure 1

P-value based ranking in ontology enrichment analysis. Subset N represents a complete human proteome (all proteins and complexes in MetaCore database). The subset n of these nodes corresponds to the experiment. Light green ellipse depicts the set of ontology categories, which can be hierarchically ordered, (as is the case for GO processes or MeSH disease classification). R-set is the union of all the proteins tied to the particular characteristic or category (e.g., proteins associated with at least one GO processes).