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Table 1 Comparison of modRP results to control studies

From: Convergence of genetic influences in comorbidity

Lind, et al., Published Results

Our Results, Corrected Threshold: 6.54E-08

SNP

p-value

 

SNP

Fisher

Mod Fisher

RP

Mod RP

  

Australian (Pos Control)

     

rs7530302

1.90E-09

AD/ND Comorbidity

rs7530302

5.29E-08

2.33E-07

5.60E-08

3.39E-08

rs1784300

2.60E-09

 

rs1784300

1.19E-09

2.00E-09

6.00E-09

3.57E-09

rs12882384

4.86E-08

 

rs12882384

2.16E-07

5.51E-07

1.08E-07

5.72E-08

  

Aus/Dutch (Neg Control)

     

rs2247219

6.23E-06

AD/AD/AD Meta

rs2247219

2.22E-05

2.02E-05

1.52E-05

1.41E-05

rs6705087

4.80E-06

ND/ND Meta

rs6705087

1.16E-05

1.12E-05

4.02E-06

5.64E-06

 

N/A

AD/ND/AD/AD/ND Co

rs1784300

3.31E-08

2.20E-08

1.05E-07

1.27E-07

Yu, et al., Published Results

Our Results, corrected Threshold: 8.88E-06

SNP

p-value

Single Phenotypes (Neg)

SNP

Fisher

Mod Fisher

RP

Mod RP

rs1938584

3.00E-03

Cocaine

rs1476880

1.36E-04

1.41E-04

1.32E-04

1.41E-04

rs1516003

9.00E-04

Opium

rs1333962

1.80E-02

1.16E-05

1.01E-05

1.15E-05

rs769592

2.00E-03

Nicotine

rs2194

4.20E-02

3.48E-04

3.47E-04

3.47E-04

rs1937443

4.00E-03

Alcohol

rs6505380

1.30E-05

1.37E-04

1.48E-04

1.37E-04

  1. Comparison of Lind and Yu results with results from our four tested methods. Tests that satisfied the Bonferroni correction threshold are in bold.