Effectiveness of segment modeling in 10-fold cross-validation experiments. Bars between adjacent dotted lines show improvement in the between prediction results of two models with the initial segment setting and the final segment setting in terms of AUC scores. We measured the performance improvement using 4-mer, 5-mer, and 6-mer features. For each cell type, the segment modeling algorithm identified significantly improved segment definitions. Five panels in each plot corresponds to tissue types: (A) Fibroblast, (B) HEK293, (C) HepG2, (D) Leukocytes, and (E) Trisom 21.