Figure 2

Graphical model showing multi-locus dependencies. Dynamic Bayesian network used by MULTI POOL to capture the dependence between nearby loci in a pooled sequencing experiment. Allele frequencies in the pool influence the mix of observed sequencing reads at each locus. Here, the causal allele is x₂ and its value is determined by sampling N individuals to create the pool from the population allele frequency p (where $p\ne \frac{1}{2}$ indicates association).