Figure 1

Overview of DTome: a web-based tool for drug-target interactome construction and analysis. The DTome network is designed to include three types of nodes (drug, protein and gene) and four types of relationship (adverse drug interaction, drug-target interaction, drug-gene association and target-/gene-protein interaction). The workflow includes three main steps. A) Data preparation and database construction. This step includes parsing the data from multiple databases and creation of a database. B) Generation of user-specified data and network. The user-specified data include a candidate drug or a list of drugs and four types of interactions. After merging the interactions, a DTome network is formed. C) Network analysis and visualization by the Cytoscape software. PINA: Protein Interaction Network Analysis.