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Table 11 MetaCyc pathway classes that are significantly enriched or depleted for reactions with links to KEGG

From: A systematic comparison of the MetaCyc and KEGG pathway databases

Status

Pathway class

Class size

Links

p-value

Enriched

Amino Acids Biosynthesis

112

186 260

1.4 × 10−20

Enriched

Individual Amino Acids Biosynthesis

99

174 244

4.0 × 10−19

Enriched

Amino Acids Degradation

118

222 326

2.0 × 10−17

Enriched

Purine Nucleotide Biosynthesis

19

46 56

3.2 × 10−10

Enriched

Generation Of Precursor Metabolites And Energy

162

170 304

2.6 × 10−9

Enriched

C1 Compounds Utilization And Assimilation

28

75 102

9.3 × 10−9

Enriched

Autotrophic CO2 Fixation

7

47 57

1.3 × 10−7

Enriched

CO2 Fixation

9

48 59

2.8 × 10−7

Enriched

Vitamins Biosynthesis

68

128 223

1.4 × 10−6

Enriched

Sugar Derivatives Degradation

42

109 162

3.8 × 10−6

Enriched

Sugar Alcohols Degradation

12

54 68

6.0 × 10−6

Enriched

Amines And Polyamines Biosynthesis

37

57 74

6.9 × 10−6

Enriched

Carboxylates Degradation

44

82 132

1.0 × 10−5

Enriched

Sugars Degradation

51

108 162

1.5 × 10−5

Enriched

NAD Biosynthesis

8

23 23

1.6 × 10−5

Enriched

Fermentation

46

75 106

3.6 × 10−5

Enriched

Nucleosides And Nucleotides Biosynthesis

35

69 128

6.8 × 10−5

Enriched

Nucleosides And Nucleotides Degradation

29

64 90

1.4 × 10−4

Enriched

Purine Nucleotide Salvage

13

26 28

1.7 × 10−4

Enriched

Arginine Degradation

15

35 42

4.6 × 10−4

Enriched

Purine Nucleotide De Novo Biosynthesis

6

22 30

4.9 × 10−4

Enriched

Mandelates Degradation

2

18 18

9.9 × 10−4

Enriched

Gluconeogenesis

2

23 28

1.1 × 10−3

Enriched

Glycolysis

6

27 30

2.0 × 10−3

Enriched

NAD Metabolism

11

28 33

2.1 × 10−3

Enriched

Geranylgeranyldiphosphate Biosynthesis

3

18 18

2.3 × 10−3

Enriched

Catechol Degradation

7

17 17

2.3 × 10−3

Enriched

Methionine Biosynthesis

13

29 34

4.0 × 10−3

Enriched

Photosynthesis

5

24 30

4.0 × 10−3

Enriched

Pyrimidine Nucleotide Biosynthesis

8

36 53

5.7 × 10−3

Enriched

Toluenes Degradation

13

35 46

7.2 × 10−3

Enriched

Glutamate Degradation

10

28 35

1.5 × 10−2

Enriched

Formaldehyde Assimilation

3

24 28

1.6 × 10−2

Enriched

Alcohols Degradation

17

24 30

1.6 × 10−2

Enriched

Urate Degradation

2

17 18

2.4 × 10−2

Enriched

Cobalamin Biosynthesis

9

35 46

2.5 × 10−2

Depleted

Secondary Metabolites Biosynthesis

460

579 1896

3.8 × 10−35

Depleted

Glucosinolates Biosynthesis

9

4 104

2.0 × 10−17

Depleted

Biosynthesis

1182

1459 4215

2.3 × 10−16

Depleted

Nitrogen Containing Glucosides Biosynthesis

13

11 125

8.0 × 10−15

Depleted

Hormones Degradation

24

12 124

2.7 × 10−13

Depleted

Polymeric Compounds Degradation

35

17 136

3.5 × 10−12

Depleted

Polysaccharides Degradation

33

17 127

2.0 × 10−10

Depleted

Steroids Degradation

8

2 46

4.2 × 10−6

Depleted

Polyketides Biosynthesis

13

6 62

1.5 × 10−5

Depleted

Glucosinolates Degradation

4

0 30

7.0 × 10−5

Depleted

Cholesterol Degradation

4

1 33

3.3 × 10−4

Depleted

Fatty Acid Biosynthesis

49

20 354

3.4 × 10−4

Depleted

Nitrogen Containing Secondary Compounds Degradation

18

13 77

1.0 × 10−3

Depleted

Terpenoids Biosynthesis

127

176 530

1.2 × 10−3

Depleted

Plant Hormones Degradation

15

7 55

1.6 × 10−3

Depleted

Sesquiterpenoids Biosynthesis

32

25 114

1.6 × 10−3

Depleted

Chlorotoluene Degradation

5

0 24

2.3 × 10−3

Depleted

Auxins Degradation

8

0 23

4.1 × 10−3

Depleted

Apocarotenoids Biosynthesis

4

0 20

2.4 × 10−2

Depleted

Lignans Biosynthesis

5

0 20

2.4 × 10−2

  1. Class size is the number of pathway instances for the given pathway class. The ‘Links’ column is the number of reactions among the pathways of the pathway class that have links to KEGG reactions, over the total number of reactions for the pathway class. The Bonferroni-corrected p-value from the hypergeometric test indicates the probability that the observed proportion of reactions with links within the pathway occurred by chance. Pathways with a p-value at or below a cut-off of α = 0.025 are shown. The full list may be found in the Additional file 2.