Pipeline for flooding minimization. (A) Transformation of the regulatory networks for flooding analysis as described in the text. (B) Flooding the network; for a given regulator node u with a positive total incoming fl
the following scenarios are possible for the flood fl(u,v) through the edge (u,v): (i) and (ii) if edge capacity c(u,v) is positive and is greater or smaller than the value of the incoming flood, respectively; (iii) and (iv) if edge capacity c(u,v) is negative and its absolute value is greater or smaller than the value of the incoming flood, respectively; (v) if the total incoming flood flood
is negative, then the node is down-regulated and no flood is propagated regardless of the capacity of the edge. (C) Selection of nodes/links with flood above the threshold and the reverse transformation of the network.