Figure 4
![Figure 4](http://media.springernature.com/full/springer-static/image/art%3A10.1186%2F1471-2105-14-168/MediaObjects/12859_2012_Article_5928_Fig4_HTML.jpg)
Observed AA change frequencies in human antibodies. Here we show the percent of AA that are changed in each of the seven regions of antibody structure for VH, V-KAPPA, and V-LAMBDA. Panels G and H show the percentage of nt insertions and deletions in CDR3, as this is the only region where those events are common.