Figure 3
From: Utilizing protein structure to identify non-random somatic mutations
An example of constructing the order statistics. Suppose we had 3 samples of a protein that is N amino acids long. If amino acid i has a “*” above it, that indicates that the amino acid for that sample had a non-synonymous missense mutation. The samples are then collapsed together and the number of mutations for each residue is shown above the box on the right. These counts form the order statistics. The first mutation is on residue 2 (X(1)=2), the next 3 mutations are on residue 3 (X(2)=X(3)=X(4)=3), the next mutation is on residue 5 (X(5)=5) and the last 2 mutations are on residue 6 (X(6)=X(7)=6).