Figure 6

Contributions by individual species to the prioritization of candidate genes. (a) Each phenotype offers some sort of information for prediction of human disease genes. Mouse data seem to offer the most information about human diseases, as one would expect from the quality of the data and the proximity of the species in the phylogenetic tree. Arabidopsis, which is the furthest species from human in our database, unexpectedly provides as much information as mouse on top predictions, and is second at higher ranks. (b) This scatter plot demonstrates that the information offered by each species (in this case mouse and Arabidopsis) is highly independent, and suggests that integrating data from multiple species may be useful.