Figure 9
From: Prediction of gene-phenotype associations in humans, mice, and plants using phenologs
Top candidate genes predicted for epilepsy. Each row of this chart represents a set of genes predicted with the same score. If a gene symbol is printed in bold, it or a member of its orthogroup is already known to be involved. Rows with plain-text labels are novel predictions. The depicted search makes predictions based on the k=40 nearest neighbor phenotypes (from human, mouse, chicken, zebrafish, worm, yeast, and plant), and color codes the twenty nearest neighbor phenotypes’ contributions to each prediction (the remaining twenty-one are grouped in blue, as “below top-20 phenotypes”). The top scoring gene, ARX, is predicted primarily by Proud syndrome, hydranencephaly, and Partington’s syndrome, all of which are human diseases characterized partially by seizures; but information is also drawn from a variety of plant phenotypes. These predictions were generated using an additive classifier for ease of visualization. The distance function is Pearson sample correlation, using cosine similarity as the weighting function w.