Cumulative distribution of functional index for GO categories and OMIM phenotypes. Cumulative log-log distribution of functional index (see methods) for A) GO categories, B) OMIM phenotypes (PH). Continuous curves represent the real data, while dashed curves result from 100 random permutation of real data (rand). Grey band in B corresponds to the standard deviation of the 100 randomly permuted datasets. The same band is not reported for panel A, since its thickness is comparable to the line thickness. In both cases the difference of real and permuted data is highly significant (P-value < 10e-256 Kolmogorov-Smirnov test).