Figure 3

Morphological fingerprints of those 67 genes which displayed abnormal phenotypes. Rows indicate the affiliations of the knockdown to the 20 universal phenotype classes (upper row). Rows were arranged by hierarchical average-linkage clustering. The entries of the heatmap are z-score normalized. Knockdown-specific phenotypes show a large morphological diversity. Most fingerprints are dominated by one single cluster. Red group: CREB1 and RXRA jointly take part in the circadian clock pathway; both share a common pathway with STK11. Purple group: PLK1 and KIF11 are both associated with mitotic spindle assembly. Pink group: ATM and CDKN2B have proportions for two distinct morphologies in their phenotypic-fingerprint. They both act as cell cycle checkpoint kinase at the transition from G1 to S-phase. Yellow group: ING1 and ARMC1 have a role in metal ion transport and binding.