Domain architectures of selected sequences containing NTF2-like domains. Domain architectures were predicted by Pfam . Signal peptides and transmembrane regions were predicted using Phobius . The NTF2-liks DUFs are shown in blue, zinc ribbons in green, TPRs yellow, peptidases and other hydrolases in pink, other DUFs in bright green, and signal peptides (S), lipoboxes (SL) and transmembrane regions (TM) in yellow. Panel A shows architectures with extracellular ligand-sensing or intracellular signaling domains. Panel B shows secreted and lipid-anchored architectures. Panel C shows architectures including hydrolase domains.