Table 1 Comparison of 12 different methods for mutation analysis

Grantham [13]

67,4

65,2

AA differences

PhD-SNP [16]

85,6

73,9

Conservation

Panther [15]

86,5

35,1

Conservation

SIFT [14]

87,8

64,4

Conservation

SNPs&GO [20]

72,5

77,8

Conservation, GO terms

SNAP [19]

83,4

56,5

Conservation, sequence predicted structure information

MutPred [21]

92,8

85,7

Conservation, sequence predicted structure information

nsSNPanalyzer [24]

74,5

67,6

Conservation, 3D structural features from homologs, AA properties

SNPs3D [22]

86,3

62,8

Conservation, structure information (pre-calculated from database)

PolyPhen-2 [32]

95,0

58,6

Conservation, 3D structural features from homologs, SwissProt annotations

HOPE [35]

96,1

76,1

Conservation, structural features from structure and homology models, SwissProt features, predictions, AA properties