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Table 3 Genes in proximity to the 10 loci with the most significant change in square-root arcsine methylation levels per one unit increase in log(RBC folate) using the ordinary least squares approach

From: The causal effect of red blood cell folate on genome-wide methylation in cord blood: a Mendelian randomization approach

Symbol Chr UCSC annotated features CpG Island Δ β-value P-value
DMPK; DMWD 19 Within 1000 bp of TSS; 3′UTR; Enhancer No -0.078 0.000891
DAND5 19 Within 100 bp of TSS No -0.047 0.001093
TRIML1 4 1st Exon No -0.046 0.001603
GP9 3 Within 1000 bp of TSS No 0.083 0.001762
POLL 10 Within 1500 bp of TSS Shore -0.031 0.001852
GCNT3 15 5′UTR No -0.049 0.001976
FUT2 19 Within 100 bp of TSS Shore -0.047 0.002012
GPR12 13 5′UTR Island -0.061 0.002106
FAM3D 3 Within 500 bp of TSS No -0.044 0.002132
COL16A1 1 5′UTR Shore -0.058 0.002294
  1. For each significant locus, including RefSeq symbol for gene(s) in closest proximity, chromosome, UCSC annotated feature, and relation to UCSC CpG island. Models adjusted for conception intention.