The causal effect of red blood cell folate on genome-wide methylation in cord blood: a Mendelian randomization approach

Table 3 Genes in proximity to the 10 loci with the most significant change in square-root arcsine methylation levels per one unit increase in log(RBC folate) using the ordinary least squares approach

Symbol	Chr	UCSC annotated features	CpG Island	Δ β-value	P-value
DMPK; DMWD	19	Within 1000 bp of TSS; 3′UTR; Enhancer	No	-0.078	0.000891
DAND5	19	Within 100 bp of TSS	No	-0.047	0.001093
TRIML1	4	1st Exon	No	-0.046	0.001603
GP9	3	Within 1000 bp of TSS	No	0.083	0.001762
POLL	10	Within 1500 bp of TSS	Shore	-0.031	0.001852
GCNT3	15	5′UTR	No	-0.049	0.001976
FUT2	19	Within 100 bp of TSS	Shore	-0.047	0.002012
GPR12	13	5′UTR	Island	-0.061	0.002106
FAM3D	3	Within 500 bp of TSS	No	-0.044	0.002132
COL16A1	1	5′UTR	Shore	-0.058	0.002294

For each significant locus, including RefSeq symbol for gene(s) in closest proximity, chromosome, UCSC annotated feature, and relation to UCSC CpG island. Models adjusted for conception intention.

ISSN: 1471-2105