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Table 2 Ranking of known drug targets (from the evolutionary perspective)

From: The evolutionary rate of antibacterial drug targets

Drugs KEGG KO Mean pN/pS SD Gene name; description
Cycloserine ko:K01921 0.5813 0.136342 ddl; D-alanyl-alanine synthetase A
  ko:K01775 0.4017 0.260427 alr; alanine racemase
Triclosan ko:K00208 0.2425 0.084719 fabI; enoyl-(acyl carrier protein) reductase
Trimethoprim ko:K00287 0.6356 0.265319 folA; dihydrofolate reductase
Sulphonamides ko:K00796 0.5708 0.213370 folP; dihydropteroate synthase
Fusidic acid ko:K02355 0.1284 0.104805 fusA; elongation factor G
Mupirocin ko:K01870 0.3031 0.139443 ileS; isoleucyl-tRNA synthetase
Quinolones ko:K02469 0.3063 0.167897 gyrA; DNA gyrase subunit A
  ko:K02470 0.2195 0.192711 gyrB; DNA gyrase subunit B
  ko:K02621 0.3364 0.158633 parC; DNA topoisomerase IV subunit A
  ko:K02622 0.3016 0.231233 parE; DNA topoisomerase IV subunit B
Rifampin ko:K03046 0.1263 0.047384 rpoC; DNA-directed RNA polymerase subunit beta'
  ko:K03043 0.1423 0.092346 rpoB; DNA-directed RNA polymerase subunit beta
  ko:K03040 0.4072 0.388638 rpoA; DNA-directed RNA polymerase subunit alpha
Macrolides ko:K02926 0.2090 0.242629 rplD; 50S ribosomal protein L4
  ko:K02890 0.2212 0.408734 rplV; 50S ribosomal protein L22
  ko:K02864 0.4581 0.364803 rplJ; 50S ribosomal protein L10
  ko:K02911 0.5297 0.438268 rpmF; 50S ribosomal protein L32
Tetracyclines ko:K02986 0.4107 0.343409 rpsD; 30S ribosomal protein S4
  ko:K02982 0.1927 0.187825 rpsC; 30S ribosomal protein S3
  ko:K02965 0.1139 0.171661 rpsS; 30S ribosomal protein S19
  ko:K02992 0.3173 0.327775 rpsG; 30S ribosomal protein S7
  ko:K02954 0.4495 0.467237 rpsN; 30S ribosomal protein S14
  ko:K02994 0.1578 0.203180 rpsH; 30S ribosomal protein S8
  ko:K02996 0.1692 0.216565 rpsI; 30S ribosomal protein S9
Glacycyline ko:K02952 0.6584 0.422977 rpsM; 30S ribosomal protein S13
Retapamulin ko:K02906 0.2112 0.307444 rplC; 50S ribosomal protein L3
Aminoglycosides ko:K02946 0.1711 0.293128 rpsJ, nusE; 30S ribosomal protein S10
  ko:K02878 0.1300 0.151462 rplP; 50S ribosomal protein L16
  ko:K02950 0.4372 0.425007 rpsL; 30S ribosomal protein S12
beta-lactam antibiotics ko:K07258 0.4060 0.280471 dacA; D-alanyl-D-alanine carboxypeptidase fraction A
  ko:K05515 0.2293 0.118958 mrdA; penicillin-binding protein 2
  ko:K03693 0.4693 0.000000 penicillin-binding protein 1B
  ko:K03587 0.2658 0.077185 ftsI; division specific transpeptidase (PBP3)
  ko:K00687 0.3279 0.000000 penicillin-binding protein 2B
  ko:K12553 0.4829 0.000000 penicillin-binding protein 3
  ko:K05365 0.3425 0.334610 mrcB, ponB; penicillin-binding protein 1B
  ko:K05366 0.3644 0.086939 mrcA; penicillin-binding protein 1A
  ko:K07262 0.3863 0.118514 pbpG; D-alanyl-D-alanine endopeptidase
  ko:K12556 0.3431 0.000000 penicillin-binding protein 2X
  ko:K12555 0.5859 0.000000 penicillin-binding protein 2A
  ko:K05367 0.7132 0.001414 pbpC; penicillin-binding protein 1C
  ko:K07259 0.3973 0.161482 dacB; D-alanyl-D-alanine carboxypeptidase/endopeptidase
Fosfomycin ko:K00790 0.2551 0.183465 murA; UDP-N-acetylglucosamine 1-carboxyvinyltransferase
  1. Drug targets are ordered by drug class. Mean pN/pS as well as standard deviation (SD) were calculated using data from eight species analyzed in the study.