Table 2 Ranking of known drug targets (from the evolutionary perspective)

Cycloserine

ko:K01921

0.5813

0.136342

ddl; D-alanyl-alanine synthetase A

ko:K01775

0.4017

0.260427

alr; alanine racemase

Triclosan

ko:K00208

0.2425

0.084719

fabI; enoyl-(acyl carrier protein) reductase

Trimethoprim

ko:K00287

0.6356

0.265319

folA; dihydrofolate reductase

Sulphonamides

ko:K00796

0.5708

0.213370

folP; dihydropteroate synthase

Fusidic acid

ko:K02355

0.1284

0.104805

fusA; elongation factor G

Mupirocin

ko:K01870

0.3031

0.139443

ileS; isoleucyl-tRNA synthetase

Quinolones

ko:K02469

0.3063

0.167897

gyrA; DNA gyrase subunit A

ko:K02470

0.2195

0.192711

gyrB; DNA gyrase subunit B

ko:K02621

0.3364

0.158633

parC; DNA topoisomerase IV subunit A

ko:K02622

0.3016

0.231233

parE; DNA topoisomerase IV subunit B

Rifampin

ko:K03046

0.1263

0.047384

rpoC; DNA-directed RNA polymerase subunit beta'

ko:K03043

0.1423

0.092346

rpoB; DNA-directed RNA polymerase subunit beta

ko:K03040

0.4072

0.388638

rpoA; DNA-directed RNA polymerase subunit alpha

Macrolides

ko:K02926

0.2090

0.242629

rplD; 50S ribosomal protein L4

ko:K02890

0.2212

0.408734

rplV; 50S ribosomal protein L22

ko:K02864

0.4581

0.364803

rplJ; 50S ribosomal protein L10

ko:K02911

0.5297

0.438268

rpmF; 50S ribosomal protein L32

Tetracyclines

ko:K02986

0.4107

0.343409

rpsD; 30S ribosomal protein S4

ko:K02982

0.1927

0.187825

rpsC; 30S ribosomal protein S3

ko:K02965

0.1139

0.171661

rpsS; 30S ribosomal protein S19

ko:K02992

0.3173

0.327775

rpsG; 30S ribosomal protein S7

ko:K02954

0.4495

0.467237

rpsN; 30S ribosomal protein S14

ko:K02994

0.1578

0.203180

rpsH; 30S ribosomal protein S8

ko:K02996

0.1692

0.216565

rpsI; 30S ribosomal protein S9

Glacycyline

ko:K02952

0.6584

0.422977

rpsM; 30S ribosomal protein S13

Retapamulin

ko:K02906

0.2112

0.307444

rplC; 50S ribosomal protein L3

Aminoglycosides

ko:K02946

0.1711

0.293128

rpsJ, nusE; 30S ribosomal protein S10

ko:K02878

0.1300

0.151462

rplP; 50S ribosomal protein L16

ko:K02950

0.4372

0.425007

rpsL; 30S ribosomal protein S12

beta-lactam antibiotics

ko:K07258

0.4060

0.280471

dacA; D-alanyl-D-alanine carboxypeptidase fraction A

ko:K05515

0.2293

0.118958

mrdA; penicillin-binding protein 2

ko:K03693

0.4693

0.000000

penicillin-binding protein 1B

ko:K03587

0.2658

0.077185

ftsI; division specific transpeptidase (PBP3)

ko:K00687

0.3279

0.000000

penicillin-binding protein 2B

ko:K12553

0.4829

0.000000

penicillin-binding protein 3

ko:K05365

0.3425

0.334610

mrcB, ponB; penicillin-binding protein 1B

ko:K05366

0.3644

0.086939

mrcA; penicillin-binding protein 1A

ko:K07262

0.3863

0.118514

pbpG; D-alanyl-D-alanine endopeptidase

ko:K12556

0.3431

0.000000

penicillin-binding protein 2X

ko:K12555

0.5859

0.000000

penicillin-binding protein 2A

ko:K05367

0.7132

0.001414

pbpC; penicillin-binding protein 1C

ko:K07259

0.3973

0.161482

dacB; D-alanyl-D-alanine carboxypeptidase/endopeptidase

Fosfomycin

ko:K00790

0.2551

0.183465

murA; UDP-N-acetylglucosamine 1-carboxyvinyltransferase