Table 1 The detected number of DE genes (at FDR = 5%), the true FDR, AUC values under HS A and HS B and the concluding characterization of targeted hypothesis setting of each method
| Â | maxP | rOP | minP | Fisher | AW | Stouffer |
|---|---|---|---|---|---|---|
Detected # | 321 | 522 | 1005 | 1000 | 1000 | 974 |
(se) | (2.2) | (2.35) | (0.85) | (1.06) | (1.05) | (1.5) |
True FDR (HS A ) | .068 | .018 | .447 | .444 | .444 | .43 |
(se) | (.0008) | (.0012) | (.0006) | (.0007) | (.0008) | (.0009) |
True FDR (HS B ) | .007 | .011 | .016 | .017 | .016 | .022 |
(se) | (.0005) | (.0004) | (.0006) | (.0006) | (.0007) | (.0006) |
AUC (HS A ) | .996 | .964 | .8 | .82 | .79 | .89 |
(se) | (.0003) | (.0014) | (.0005) | (.0005) | (.0005) | (.0006) |
AUC (HS B ) | .75 | .833 | .99 | .99 | .99 | .99 |
(se) | (.0013) | (.01) | (.0001) | (.0001) | (.0001) | (.0005) |
Characterization | HS A | HS r | HS B | HS B | HS B | HS B |
| Â | PR | SR | FEM | REM | RankProd | RankSum |
Detected # | 136 | 186 | 948 | 411 | 391 | 105 |
(se) | (2.51) | (2.3) | (1.75) | (2.86) | (3.31) | (1.514) |
True FDR (HS A ) | .008 | .01 | .415 | .117 | .13 | .389 |
(se) | (.0003) | (.0004) | (.0009) | (.0015) | (.0014) | (.0008) |
True FDR (HS B ) | 0 | 0 | .022 | .007 | 0 | 0 |
(se) | (0) | (0) | (.0007) | (.0004) | (0) | (0) |
AUC (HS A ) | .986 | .99 | .917 | .99 | .916 | .504 |
(se) | (.0003) | (.0002) | (.0009) | (.0002) | (.0011) | (.0046) |
AUC (HS B ) | .981 | .95 | .984 | .92 | .934 | .496 |
(se) | (.0004) | (.0008) | (.0004) | (.0011) | (.0012) | (.0025) |
Characterization | HS A | HS A | HS B | HS r | HS B | HS B |