Figure 3
From: Elucidating the crosstalk mechanism between IFN-gamma and IL-6 via mathematical modelling
Dependency of JAK/STAT pathway activation on the initial concentrations of STATs. (A) The activation of STAT1 was mainly independent of the concentration of STAT3 after IFN-gamma simulation. (B) The concentration of STAT3 significantly affected the activation of STAT1 after IL-6 simulation. (C) The activation of STAT3 was mainly independent of the concentration of STAT1 after IL-6 simulation. (D) The concentration of STAT1 significantly affected the activation of STAT3 after IFN-gamma simulation. (E) Recruitment from STAT1 to (IFN-R-JAK)2* was mainly independent of the concentration of STAT3 after IFN-gamma simulation. (F) The concentration of STAT1 significantly affected recruitment from STAT3 to (IFN-R-JAK)2*.