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Table 1 DiGs related only to complexes found in n-ary data

From: A survey of protein interaction data and multigenic inherited disorders

DiG ID DiG name # Genes Best match (icrigid) Complex span # significant p-values (raw) # significant p-values (FDR)
6 3-methylcrotonyl-coa carboxylase 2 1209480 9 9 2
65 Albinism 3 1209579 1 1 1
80 alport syndrome 3 781937 4 4 1
89 Amyloidosis 6 1221863 26 22 9
168 bethlem myopathy 3 1027975 5 5 1
192 Bradyopsia 2 969965 1 1 1
259 Ceroid 8 1232651 6 3 1
302 combined cellular and humoral immune defects 2 1220789 1 1 1
313 congenital disorder of glycosylation 23 725907 28 26 4
578 Hematuria 2 781937 4 4 1
595 hereditary hemorrhagic telangiectasia 2 618400 1 1 1
690 immune dysfunction 2 1122614 5 5 2
758 leigh syndrome 14 1211293 44 36 13
812 maple syrup urine disease 4 1225549 12 11 1
870 mitochondrial complex 16 1211293 28 24 5
975 omenn syndrome 3 1220789 1 1 1
998 Osteoporosis 5 869728 5 5 2
1108 Propionicacidemia 2 1209480 5 5 2
1266 stickler syndrome 3 878437 4 4 1
1341 tumoral calcinosis 4 682939 3 3 1
1345 ullrich congenital muscular dystrophy 3 1027975 5 5 1
1477 celiac disease 4 1220318 2 1 1
1512 intervertebral disc disease 2 893696 1 1 1
1520 Leprosy 4 651466 7 7 1
  1. Summary of the 24 DiGs that can be related to protein complexes but can only be found in iRefIndex n-ary data: Mitochondrial complex deficiency (DiG ID = 870) is a DiG that groups 16 genes. At least one of the 16 genes in this DiG was present in 28 complexes present in iRefIndex n-ary data (complex span = 28) and 24 of them could be considered as significantly similar after a hypergeometric test with a p-value < 0.05. After adjusting the p-values for multiple testing using the FDR method, only 5 of those complexes could be considered significantly similar to the DiG, and therefore, their subunits related to the diseases involved in the DiG. The best match, among those 5, is the complex with the icrigid = 1211293, which corresponds to the complex in the CORUM database with interaction identifier = 15317750.
  2. “3-methylcrotonyl-coa carboxylase” stands for “3-methylcrotonyl-coa carboxylase 1 deficiency” and “3-methylcrotonyl-coa carboxylase 2 deficiency”, while “Ceroid” stands for “Ceroid lipofuscinosis” and “Mitochondrial complex” stands for Mitochondrial complex I, II, III and IV deficiencies.