A survey of protein interaction data and multigenic inherited disorders

BMC Bioinformatics

Table 6 Comparison of results using iRefIndex version 8.0 and iRefIndex 9.0

Variable	iRefIndex 8.0	iRefIndex 9.0
# Human-Human Interaction records	319447	361059
# Genes in Morbid Map with PI info in iRefIndex	1685	1719
# Genes in Morbid Map without PI info in iRefIndex	256	222
# DiGs with non-translatable genes	166	156
# n-ary groups	4827	5677
# regenerated groups	7830	9947
# binary nodes in PIN	15597	16272
# binary edges in PIN	98853	113733
# significant matches DiG-nary	81	94
# significant matches DiG-regenerated	96	105
# binary-enriched DiGs	84	87
# all significant DiGs	220	227
# DiG matching only nary data	16	24
# DiG matching only regenerated data	22	25
# DiG matching only binary data	21	20
# databases with nary data matching DiGs	6	7
# databases with regenerated data matching DiGs	3	3
# nary groups with lpr < 22 (low-throughput)	53	61
# Matches found using KEGG and not found using iRefIndex	77	68

The first 8 rows show how knowledge about the human interactome grows from one database release to the next; that is, the growth of the number of interaction records (319447 to 361059), the number of genes associated to disease in OMIM having interaction information in iRefIndex (1685 to 1719), the number of complexes coming from n-ary (4827 to 5677) and regenerated (7830 to 9947) data, and the number of binary nodes and edges in the PIN. This leads to an increase in the number of matches between DiGs and each of the three data sources (nary, regenerated, binary) and, in total, an increase from 220 to 227 matching DiGs from one release to the following one. The number of DiGs matching only one type of data also grows, as well as the number of databases with n-ary data matching DiGs.

ISSN: 1471-2105