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Table 6 Comparison of results using iRefIndex version 8.0 and iRefIndex 9.0

From: A survey of protein interaction data and multigenic inherited disorders

Variable iRefIndex 8.0 iRefIndex 9.0
# Human-Human Interaction records 319447 361059
# Genes in Morbid Map with PI info in iRefIndex 1685 1719
# Genes in Morbid Map without PI info in iRefIndex 256 222
# DiGs with non-translatable genes 166 156
# n-ary groups 4827 5677
# regenerated groups 7830 9947
# binary nodes in PIN 15597 16272
# binary edges in PIN 98853 113733
# significant matches DiG-nary 81 94
# significant matches DiG-regenerated 96 105
# binary-enriched DiGs 84 87
# all significant DiGs 220 227
# DiG matching only nary data 16 24
# DiG matching only regenerated data 22 25
# DiG matching only binary data 21 20
# databases with nary data matching DiGs 6 7
# databases with regenerated data matching DiGs 3 3
# nary groups with lpr < 22 (low-throughput) 53 61
# Matches found using KEGG and not found using iRefIndex 77 68
  1. The first 8 rows show how knowledge about the human interactome grows from one database release to the next; that is, the growth of the number of interaction records (319447 to 361059), the number of genes associated to disease in OMIM having interaction information in iRefIndex (1685 to 1719), the number of complexes coming from n-ary (4827 to 5677) and regenerated (7830 to 9947) data, and the number of binary nodes and edges in the PIN. This leads to an increase in the number of matches between DiGs and each of the three data sources (nary, regenerated, binary) and, in total, an increase from 220 to 227 matching DiGs from one release to the following one. The number of DiGs matching only one type of data also grows, as well as the number of databases with n-ary data matching DiGs.