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Table 1 HLA class II crystal structures employed to identify SDRs

From: PREDIVAC: CD4+ T-cell epitope prediction for vaccine design that covers 95% of HLA class II DR protein diversity

Allele Peptide sequence PDB IDs
DRB1*0101 AAYSDQATPLL LS 1T5X; 1T5W
AGFKGEQGPKG EPG 2FSE
PEVIPMFSALS EGAT 1SJE
PEVIPMFSALS EG 1SJH
GELIGILNAAKV PAD 1KLG; 2IAM
GELIGTLNAAKV PAD 1KLU; 2IAN
GSDWRFLRGYHQ YA 1AQD
PKYVKQNTLKL AT 1DLH; 1FYT; 1HXY; 1JWM; 1JWS; 1JWU; 1KG0; 1LO5; 2G9H; 2ICW; 2OJE; 1R5I
DRB1*0301 PVSKMRMATPLLM QA 1A6A
DRB1*0401 AYMRADAAAGG A 2SEB
PKYVKQNTLKL AT 1J8H
DRB1*1501 ENPVVHFFKNIVT P 1BX2; 1YMM
MDFARVHFISALHG LGGG 2WBJ
DRB3*0101 AWRSDEALPL G 2Q6W
DRB3*0301 QVIILNHPGQI SA 3C5J
DRB5*0101 GGVYHFVKKHVH ES 1H15
NPVVHFFKNIVTPRT PPPSQ 1FV1
VHFFKNIVTPRT PG 1ZGL
DQB1*0201 LQPFPQPELPY 1S9V
DQB1*0602 MNLPSTKVSWA AVGGGGSLV 1UVQ
DQB1*0302 SGEGSFQPSQE NP 2NNA
LVEALYLVCGE RGG 1JK8
  1. The binding cores of the peptide ligands are highlighted in bold. Underlined PDB IDs represent the structures that were employed for structural alignment.