Figure 1

Part of blood coagulation pathway downloaded from GeneGO Inc. Interactions are colored by mechanism; grey for binding (B), green for cleavage (C) and blue for transformation (TR). Solid lines indicate active interactions (the active subnetwork), while dotted lines indicate the remaining non-active interactions. The figure highlights a region of the active subnetwork rich in interactions of pairs {C,C},{C,T} and {T,T}. In the active subnetwork, Thrombin cleaves two protein receptors (PAR1 and PAR4). These receptors then transform G-protein alpha-13, enabling it to effect the blood coagulation process further. On the contrary, there is no strong correlation for the pair {B,T}, as about the same number of I-I pairs with this label are in the same state (e.g., G-protein alpha-q (B) LARG (active), LARG (T) RhoA (active)), as in a different state (e.g., PAR4 (T) G-protein alpha-13 (active),G-protein alpha-13 (B) ARHGEf1 (not active)).