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Table 9 Contribution of each of uBLU’s constraints

From: Unsupervised Bayesian linear unmixing of gene expression microarrays

 

Without

Positivity

Sum-to-one

Positivity and

 

constraints

  

sum-to-one

P-value of the “IFN-gamma pathway”

6.00.10−2

2.05.10−2

2.17.10−1

1.34.10−9

P-value of the “IL23-mediated signaling events”

2.60.10−1

8.37.10−2

2.28.10−2

2.18.10−7

  1. Benefit of constraints in uBLU in terms of gene enrichment in the NCI-curated IFN-gamma and IL23-mediated pathways. As in Tables 6 and 8, the top 200 genes in the inflammatory components, whose scores are shown in Figures 6(a-d), were analyzed using the NCI Pathway Interaction Database. Both positivity and sum-to-one constraints are necessary for uBLU to reveal these two pathways with the high significance (p-value less than 10−6).
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BMC Bioinformatics

ISSN: 1471-2105

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