
Without

Positivity

Sumtoone

Positivity and



constraints
  
sumtoone


Pvalue of the “IFNgamma pathway”

6.00.10^{−2}

2.05.10^{−2}

2.17.10^{−1}

1.34.10^{−9}

Pvalue of the “IL23mediated signaling events”

2.60.10^{−1}

8.37.10^{−2}

2.28.10^{−2}

2.18.10^{−7}

 Benefit of constraints in uBLU in terms of gene enrichment in the NCIcurated IFNgamma and IL23mediated pathways. As in Tables 6 and 8, the top 200 genes in the inflammatory components, whose scores are shown in Figures 6(ad), were analyzed using the NCI Pathway Interaction Database. Both positivity and sumtoone constraints are necessary for uBLU to reveal these two pathways with the high significance (pvalue less than 10^{−6}).