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Table 3 Predicted binding affinity of three NA inhibitors with the novel H7N9, H5N1, and H1N1 neuraminidases

From: Structural analysis of the novel influenza A (H7N9) viral Neuraminidase interactions with current approved neuraminidase inhibitors Oseltamivir, Zanamivir, and Peramivir in the presence of mutation R289K

NA inhibitor Binding affinity (kcal/mol)
Novel H7N9 H5N1 [PDB id] H1N1 [PDB id]
[2HTU] [2HU0] [2HU4] [3TI6] [3B7E] [3TI5]
oseltamivir -7.49 -8.65 -8.30 -8.33 (2.26)* -8.18 (1.82)* -8.28 -8.16
peramivir -7.20 -8.53 (1.6)* -7.35 -7.94 -7.78 -7.81 -7.96
zanamivir -6.33 -7.08 -6.94 -6.71 -6.92 -7.27 (0.69)* -7.32 (0.92)*
  1. * Root Mean Square deviation (RMSD) of the docked complex to the native complex structures