Figure 1
From: Identifying conserved protein complexes between species by constructing interolog networks
Conservation of complexes between yeast and human. Many proteins in yeast have either 'split' into multiple proteins or fused into common proteins in human during evolution. This mechanism is a result of selecting optimal protein assemblies [14] thereby resulting in multi-fold expansion of complexity in human. In order to capture these conservation mechanisms it is necessary to integrate domain along with PPI information.