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Table 10 Homology data: Ensembl and OrthoMCL

From: Identifying conserved protein complexes between species by constructing interolog networks

  

Ensembl database

OrthoMCL database

# Ortholog groups:

# 1-to-1 groups

1096

1153

 

# 1-Yeast-to-many groups

756

434

 

# 1-Human-to-many groups

116

116

 

# many-to-many groups

197

167

 

Total:

2165 (5503 pairs)

1870

# Human paralog groups:

2573

2435

# Yeast paralog groups:

426

393

Total # homolog groups:

5164

4698

  1. Ensembl [17] contains protein orthologs based on sequence similarity as well as domain information, while OrthoMCL [18] is predominantly based on sequence similarity. As we can see from the table, using domain information (through Ensembl) generates significantly more many-to-many ortholog mappings thereby enhancing our interolog construction.
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BMC Bioinformatics

ISSN: 1471-2105

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