Skip to main content

Table 10 Homology data: Ensembl and OrthoMCL

From: Identifying conserved protein complexes between species by constructing interolog networks

   Ensembl database OrthoMCL database
# Ortholog groups: # 1-to-1 groups 1096 1153
  # 1-Yeast-to-many groups 756 434
  # 1-Human-to-many groups 116 116
  # many-to-many groups 197 167
  Total: 2165 (5503 pairs) 1870
# Human paralog groups: 2573 2435
# Yeast paralog groups: 426 393
Total # homolog groups: 5164 4698
  1. Ensembl [17] contains protein orthologs based on sequence similarity as well as domain information, while OrthoMCL [18] is predominantly based on sequence similarity. As we can see from the table, using domain information (through Ensembl) generates significantly more many-to-many ortholog mappings thereby enhancing our interolog construction.