Figure 1

Conceptual model. Figure shows the logic implemented into the model, including the genetic predisposition in developing the pathology (i.e. thyms selection of self-reactive clones), the presence of an external trigger (i.e. EBV), the supposed malfunction of the Treg-Teff mechanism, and the effects caused by the malfunction (i.e. neural damage due to myelin loss). Self-reactive resting Teff and Treg cells are introduced by Thymus selection. An external factor such as EBV latent infection can cause activation of both Teff and Treg cells. Activated Teff cells can then attack myelin causing damage in the brain and duplicate, activated Treg will downregulate Teff receiving a positive feedback from that. reversible damage can be recovered.