Damage progression vs time in hill patients. Simulation of eight randomly-selected hill virtual patients. Simulation time is 5 years (18250 time-steps). Red lines represent activated unrecoverable damage, blue lines represent recoverable damage and black lines total damage (recoverable + unrecoverable). In this case it is possible to observe more frequent spikes in the reversible damage curves. Furthermore unrecoverable damage (that can be correlated with the appearing MS plaques) is also present.