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Table 3 Top 20 term associations in category "non-overlap" that were identified by CroGO.

From: Identifying cross-category relations in gene ontology and constructing genome-specific term association networks

MF Name

BP Name

Evidence

endopeptidase activator activity

proteasome core complex assembly

NEW

TFIIF-class binding TF activity

regulation of histone H3 K79 methylation

NEW

RNA-directed RNA polymerase activity

DNA-dependent transcriptional start site selection

LEXICAL

RNA-directed RNA polymerase activity

transcriptional start site selection at Pol II promoter

LEXICAL

single base insertion or deletion binding

chiasma assembly

REF [26]

double-strand/single-strand DNA junction binding

chiasma assembly

REF [26]

double-stranded telomeric DNA binding

gene conversion at mating-type locus, DNA double-strand break processing

NEW

G-quadruplex DNA binding

gene conversion at mating-type locus, DNA double-strand break processing

NEW

very long-chain fatty acid-CoA ligase activity

long-chain fatty-acyl-CoA metabolic process

REF [27]

very long-chain fatty acid-CoA ligase activity

fatty-acyl-CoA metabolic process

REF [27]

very long-chain fatty acid-CoA ligase activity

acyl-CoA metabolic process

REF [27]

single base insertion or deletion binding

meiotic heteroduplex formation

NEW

guanine/thymine mispair binding

chiasma assembly

NEW

TFIIE-class TF binding

negative regulation of ribosomal protein gene transcription from Pol II promoter in response to chemical stimulus

REF [28]

TFIIE-class binding TF activity

negative regulation of ribosomal protein gene transcription from Pol II promoter in response to chemical stimulus

REF [28]

Hsp90 protein binding

positive regulation of telomere maintenance via telomerase

NEW

Hsp90 protein binding

positive regulation of telomere maintenance

REF [29]

Hsp90 protein binding

positive regulation of homeostatic process

REF [30]

aldehyde dehydrogenase activity

beta-alanine metabolic process

REF [31]

aldehyde dehydrogenase activity

beta-alanine biosynthetic process

REF [31]

  1. Top 20 term associations in category "non-overlap" that were identified by CroGO. In the list, 11 term associations are supported by the existing biological studies, 2 are supported by the lexical matching on term definition, and the rest 7 are new conceptual connections that cannot be found in any literature. None of the term associations can be identified by the VSM or ASR based measures.