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Table 3 Top 20 term associations in category "non-overlap" that were identified by CroGO.

From: Identifying cross-category relations in gene ontology and constructing genome-specific term association networks

MF Name BP Name Evidence
endopeptidase activator activity proteasome core complex assembly NEW
TFIIF-class binding TF activity regulation of histone H3 K79 methylation NEW
RNA-directed RNA polymerase activity DNA-dependent transcriptional start site selection LEXICAL
RNA-directed RNA polymerase activity transcriptional start site selection at Pol II promoter LEXICAL
single base insertion or deletion binding chiasma assembly REF [26]
double-strand/single-strand DNA junction binding chiasma assembly REF [26]
double-stranded telomeric DNA binding gene conversion at mating-type locus, DNA double-strand break processing NEW
G-quadruplex DNA binding gene conversion at mating-type locus, DNA double-strand break processing NEW
very long-chain fatty acid-CoA ligase activity long-chain fatty-acyl-CoA metabolic process REF [27]
very long-chain fatty acid-CoA ligase activity fatty-acyl-CoA metabolic process REF [27]
very long-chain fatty acid-CoA ligase activity acyl-CoA metabolic process REF [27]
single base insertion or deletion binding meiotic heteroduplex formation NEW
guanine/thymine mispair binding chiasma assembly NEW
TFIIE-class TF binding negative regulation of ribosomal protein gene transcription from Pol II promoter in response to chemical stimulus REF [28]
TFIIE-class binding TF activity negative regulation of ribosomal protein gene transcription from Pol II promoter in response to chemical stimulus REF [28]
Hsp90 protein binding positive regulation of telomere maintenance via telomerase NEW
Hsp90 protein binding positive regulation of telomere maintenance REF [29]
Hsp90 protein binding positive regulation of homeostatic process REF [30]
aldehyde dehydrogenase activity beta-alanine metabolic process REF [31]
aldehyde dehydrogenase activity beta-alanine biosynthetic process REF [31]
  1. Top 20 term associations in category "non-overlap" that were identified by CroGO. In the list, 11 term associations are supported by the existing biological studies, 2 are supported by the lexical matching on term definition, and the rest 7 are new conceptual connections that cannot be found in any literature. None of the term associations can be identified by the VSM or ASR based measures.
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BMC Bioinformatics

ISSN: 1471-2105

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