Table 2 2009-H1N1 HA epitope interacting residues with DM1-TCR and HLA-B*4405 complexes.
Position | Epitope sequence | HLA/epitope (solvent-exposed residues) | TCR-HLA/epitope (interacting residues) |
|---|---|---|---|
50 | LEDKHNGKL | Lys4 | Lys4 |
128 | FERFEIFPK | Arg3, Glu5 | Arg3 |
188 | KEVLVLWGI | - | Lys1, Leu4, Leu6, Gly8 |
251 | VEPGDKITF | Asp5, Lys6 | Asp5, Lys6 |
412 | KEFNHLEKR | Asn4, His5, Glu7 | Glu2, Asn4, His5, Glu7 |
446 | LENERTLDY | - | Leu1, Glu4, Asp8 |
463 | YEKVRSQLK | Arg5 | Arg5, Lys9 |
493 | MESVKNGTY | Met1 | Met1, Lys5 |
514 | REEIDGVKL | Lys8 | Lys8 |
131 | FEIFPKTSS | Phe1 | Phe1, Lys6 |
229 | PEIAIRPKV | Ala4, Ile5 | Ile5 |
400 | IEKMNTQFT | Lys3, Met4 | Glu2, Lys3, Met4, Asn5, Thr6 |
421 | IENLNKKVD | - | Lys7, Asp9 |
475 | KEIGNGCFE | - | Lys1, Glu2 |
482 | FEFYHKCDN | - | Lys6 |
240 | QEGRMNYYW | - | Asn6, Tyr7, Tyr8, Trp9 |
259 | FEATGNLVV | Thr4, Gly5, Asn6 | Glu2, Thr4, Gly5 |