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Table 10 Evaluation of iStable prediction results with data from different protein superfamilies

From: iStable: off-the-shelf predictor integration for predicting protein stability changes

Protein categories Predictors Sn Sp Acc MCC
Nucleic acid binding      
  iStable 0.550 0.943 0.795 0.567
  I-Mutant_PDB 0.550 0.852 0.742 0.439
  I-Mutant_SEQ 0.300 0.943 0.704 0.343
  AUTO-MUTE_RF 0.250 0.971 0.704 0.359
  AUTO-MUTE_SVM 0.250 0.943 0.684 0.262
  MUPRO_SVM 0.450 0.857 0.704 0.395
  PoPMuSiC2.0 0.400 0.910 0.724 0.355
  CUPSAT 0.350 0.552 0.476 -0.073
Enzyme      
  iStable 0.451 0.797 0.720 0.334
  I-Mutant_PDB 0.253 0.869 0.756 0.135
  I-Mutant_SEQ 0.242 0.878 0.762 0.131
  AUTO-MUTE_RF 0.138 0.978 0.825 0.217
  AUTO-MUTE_SVM 0.057 0.965 0.800 0.049
  MUPRO_SVM 0.281 0.859 0.753 0.144
  PoPMuSiC2.0 0.344 0.931 0.824 0.328
  CUPSAT 0.390 0.740 0.676 0.112
Protein-protein interaction related      
  iStable 0.357 0.943 0.831 0.379
  I-Mutant_PDB 0.207 0.858 0.733 0.088
  I-Mutant_SEQ 0.361 0.798 0.714 0.161
  AUTO-MUTE_RF 0.129 0.965 0.805 0.145
  AUTO-MUTE_SVM 0.079 0.970 0.799 0.100
  MUPRO_SVM 0.204 0.864 0.737 0.076
  PoPMuSiC2.0 0.100 0.964 0.798 0.091
  CUPSAT 0.461 0.778 0.717 0.216