Daphnia's paralogs of Ryanodine and IP3 receptor families. (A) Dendogram based on multiple sequence alignment (MSA) of IP3 receptors including the Daphnia protein E9HHK2. The Daphnia proteins (red symbol) intermix with IP3 receptor proteins from other organisms. (B) A schematic view of the collection of Ryanodine like receptors according to their domain architectures and based on InterPro (Ryanodine receptors and Ca2+ release channel). The domains according to Pfam are also listed (rectangle symbols). Interestingly, most Daphnia's proteins in the cluster are shorter than the average length of the Ryanodine and IP3 receptors. Only 8/51 Daphnia paralogs failed to meet the InterPro definition of 'Ryanodine related receptor'. Notably, the analyzed ProRoot70 ID 4478501 (65 proteins) contains proteins from human, fruitfly, unicellular ciliate protozoa and Paramecium. The Daphnia proteins presented are those with a minimal length of 350 amino acids.