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Table 1 The sequences with the top ten "most informatively" predicted correct annotations by the aggregate algorithm are summarized.

From: Characterizing the state of the art in the computational assignment of gene function: lessons from the first critical assessment of functional annotation (CAFA)

Sequence Gene symbol Gold standard Closest informative prediction Pre-existing IEA terms (representative) Pub Date
BHMT1_MOUSE Bhmt methionine biosynthetic process (GO:0009086) methionine biosynthetic process (GO:0009086) methionine biosynthetic process 2004
IPO13_RAT Ipo13 steroid hormone receptor nuclear translocation (GO:0002146) protein import into nucleus, translocation (GO:0000060) protein import into nucleus 2006
ARGB_ECOLI argb arginine biosynthetic process (GO:0006526) arginine biosynthetic process (GO:0006526) arginine biosynthetic process 2007
CAF1K_ARATH CAF1-11 nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289) nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289) poly(A)-specific ribonuclease activity 2009
CFAB_MOUSE Cfb complement activation, alternative pathway (GO:0006957) complement activation, alternative pathway (GO:0006957) complement activation 1983
CHM4B_HUMAN CHMP4B endosome transport (GO:0016197) endosome transport (GO:0016197) protein transport; late endosome membrane 2010 (Reactome)
HA15_MOUSE H2-T23 antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway (GO:0002488) antigen processing and presentation of endogenous peptide antigen via MHC class Ib (GO:0002476) antigen processing and presentation of peptide antigen via MHC class I 1992
SOX11_MOUSE Sox11 positive regulation of hippo signaling pathway (GO:0035332) embryonic digestive tract morphogenesis (GO:0048557) cell differentiation;nervous system development 2010
TGT_ECOLI tgt tRNA wobble guanine modification (GO:0002099) queuosine metabolic process (GO:0046116) queuine tRNA-ribosyltransferase activity 1982
VATL_MOUSE Atp6v0c lysosomal lumen acidification (GO:0007042) lysosomal lumen acidification (GO:0007042) proton-transporting V-type ATPase, V0 domain;vacuole 2001
  1. The date of publication of the gold standard source is given in the last column.
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BMC Bioinformatics

ISSN: 1471-2105

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