Table 1 The sequences with the top ten "most informatively" predicted correct annotations by the aggregate algorithm are summarized.
Sequence | Gene symbol | Gold standard | Closest informative prediction | Pre-existing IEA terms (representative) | Pub Date |
|---|---|---|---|---|---|
BHMT1_MOUSE | Bhmt | methionine biosynthetic process (GO:0009086) | methionine biosynthetic process (GO:0009086) | methionine biosynthetic process | 2004 |
IPO13_RAT | Ipo13 | steroid hormone receptor nuclear translocation (GO:0002146) | protein import into nucleus, translocation (GO:0000060) | protein import into nucleus | 2006 |
ARGB_ECOLI | argb | arginine biosynthetic process (GO:0006526) | arginine biosynthetic process (GO:0006526) | arginine biosynthetic process | 2007 |
CAF1K_ARATH | CAF1-11 | nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289) | nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289) | poly(A)-specific ribonuclease activity | 2009 |
CFAB_MOUSE | Cfb | complement activation, alternative pathway (GO:0006957) | complement activation, alternative pathway (GO:0006957) | complement activation | 1983 |
CHM4B_HUMAN | CHMP4B | endosome transport (GO:0016197) | endosome transport (GO:0016197) | protein transport; late endosome membrane | 2010 (Reactome) |
HA15_MOUSE | H2-T23 | antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway (GO:0002488) | antigen processing and presentation of endogenous peptide antigen via MHC class Ib (GO:0002476) | antigen processing and presentation of peptide antigen via MHC class I | 1992 |
SOX11_MOUSE | Sox11 | positive regulation of hippo signaling pathway (GO:0035332) | embryonic digestive tract morphogenesis (GO:0048557) | cell differentiation;nervous system development | 2010 |
TGT_ECOLI | tgt | tRNA wobble guanine modification (GO:0002099) | queuosine metabolic process (GO:0046116) | queuine tRNA-ribosyltransferase activity | 1982 |
VATL_MOUSE | Atp6v0c | lysosomal lumen acidification (GO:0007042) | lysosomal lumen acidification (GO:0007042) | proton-transporting V-type ATPase, V0 domain;vacuole | 2001 |