Figure 3
From: An optimized algorithm for detecting and annotating regional differential methylation
DMR analysis and output of eDMR for leukemia samples. (A) Fitting of the bimodal normal distribution to CpGs common to the IDH AML and normal bone marrow control samples. (B) Fitting of the bimodal normal distribution to CpGs common to the MLL AML and normal bone marrow control samples. Both data have similar distributions. (C) The number of hypermethylated (red) and hypomethylated (blue) DMRs identified in each leukemia subtype. (D) Boxplots of the DMR length distributions in both leukemia subtypes. (E) Gene body distributions for CDS (red), introns (mustard), promoters (green), 3'UTRs (blue), and 5'UTRs (purple). (F) CpG island (red) and shore (blue) DMR count distribution in the IDH and MLL AML tumor-types.