Simulating the decentralized processes of the human immune system in a virtual anatomy model

BMC Bioinformatics

Table 1 Simulation Parameters.

	Name	Value
	1 day	200 time steps
Virus	Lifetime	200 time steps (24h)
	incubation time	150 time steps (18h)
	probability of infection	0.1
	number of viruses released	5
B Cell	short lifetime	2500 time steps (10.5d)
	long lifetime	3000000 time steps (>40yr)
	probability of becoming memory	0.2
	number of clones generated	5
	antibodies released	20
	probability of releasing antibodies	0.05
T Cell	short lifetime	2500 time steps (10.5d)
	long lifetime	3000000 time steps (>40yr)
	probability of killing infected cell (CD8)	0.1
	probability of becoming memory	0.2
Dendridic Cell	probability of apoptosis (contact with CD4 T cell)	0.001
	probability of activation (contact with virus)	0.1
Antibody	Lifetime	500 time steps (2.5d)
	probability of neutralization of virus	0.5
Epithelial Cell	probability of reproduction	0.002

The default biological parameters used in our simulations. All probabilities are computed once per time step. In order to set up a realistic time scale, 200 time steps is equivalent to 1 day.

ISSN: 1471-2105