Figure 1

Illustration of model parameters and immunohistological interpretation of sections from mixed GCs. A, Cartoon showing B cells from a mixed population with phenotypes A and B founding a GC. B, Cartoon representing B cell expansion in a mixed GC, and the possible appearance of its immunohistological sections. C, Simulation of immunofluorescence staining of GC sections with Abs for B cells of type A allotype. Each panel simulates a GC section with a total of 202 cells, of which 80% are assumed to be randomly localized B lymphocytes [8, 20]. Non-homogeneous staining of cells, as is typically observed, is also incorporated. Panels (i) to (iv) are, respectively, from GCs with 100%, 70%, 50%, and 40% B cells of type A.