Table 9 Biclusters containing co-targeting on KAT2B

Hierarchy level 1

41

0.40

0.05

1.00

miR-181a, miR-181b

NLK

Serine/threonine-protein kinase that regulates a number of transcription factors with key roles in cell fate determination. Positive effector of the non-canonical Wnt signaling pathway and negative regulator of the canonical Wnt/beta-catenin signaling pathway and of Notch signaling pathway

none

BCL2*

Integral outer mitochondrial membrane protein that regulate and contribute to programmed cell death or apoptosis

none

CDX2

Transcription factor. Important in broad range of functions from early differentiation to maintenance of the intestinal epithelial lining of both the small and large intestine

none

GATA6

Member of a small family of zinc finger transcription factors that play an important role in the regulation of cellular differentiation and organogenesis during vertebrate development

none

KAT2B*

Functions as a histone acetyltransferase (HAT) to promote transcriptional activation. Inhibits cell-cycle progression

none

PLAG1

Transcription factor whose activation results in up-regulation of target genes, such as IGFII, leading to uncontrolled cell proliferation: when overexpressed in cultured cells, higher proliferation rate and transformation are observed

none

65

1.00

1.00

1.00

miR-25, miR-32,miR-19a

KAT2B*

Functions as a histone acetyltransferase (HAT) to promote transcriptional activation. Inhibits cell-cycle progression

none

PRMT5

Protein arginine methyltransferase 5. Plays a role in the assembly of snRNP core particles. May play a role in cytokine-activated transduction pathways. Negatively regulates cyclin E1 promoter activity and cellular proliferation

none

BCL2L11

Integral outer mitochondrial membrane protein that regulate and contribute to programmed cell death or apoptosis.

none

Hierarchy level 2

16-65

1.00

0.07

0.639

miR-25, miR-32, miR-19a, miR-19b

ESR1^†

Estrogen receptor. Ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues

Signal Transduction (4.9e-04) Signaling by ERBB4 (1.4e-02)

PTEN*^†

Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5- trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway

Signal Transduction (4.9e-04)

Signaling by SCF-KIT (1.2e-02)

Signaling by ERBB4 (1.4e-02)

Signalling by NGF (4.6e-02)

ATXN1^†

Chromatin-binding factor that repress Notch signaling in the absence of Notch intracellular domain by acting as a CBF1 corepressor.

none

BMPR2*^†

Member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are BMPs, which are members of the TGF-beta superfamily.

Signal Transduction (4.9e-04)

KAT2B*

Functions as a histone acetyltransferase (HAT) to promote transcriptional activation. Inhibits cell-cycle progression.

Signal Transduction (4.9e-04)

PRMT5

Protein arginine methyltransferase 5. Plays a role in the assembly of snRNP core particles. May play a role in cytokine-activated transducion pathways. Negatively regulates cyclin E1 promoter activity and cellular proliferation.

Signal Transduction (4.9e-04)

SOCS1

Suppressor of cytokine signalling. SOCS1 is involved in negative regulation of cytokines that signal through the JAK/STAT3 pathway.

Signaling by SCF-KIT (1.2e-02)

TGFBR2*^†

Transforming growth factor, beta receptor II. Transmembrane protein that has a protein kinase domain, forms a heterodimeric complex with TGFBR1, and binds TGF-beta. This receptor/ligand complex phosphorylates proteins, which then enter the nucleus and regulate the transcription of a subset of genes related to cell proliferation.

Signal Transduction (4.9e-04)

BCL2L11

Transforming growth factor, beta receptor II. Transmembrane protein that has a protein kinase domain, forms a heterodimeric complex with TGFBR1, and binds TGF-beta. This receptor/ligand complex phosphorylates proteins, which then enter the nucleus and regulate the transcription of a subset of genes related to cell proliferation.

Signalling by NGF (4.6e-02)