Table 2 Energy potentials (kcal/mole) computed from the propensities of amino acid residues at different positions in amyloid and non-amyloid hexa-peptides
Amyloid | Position | |||||
|---|---|---|---|---|---|---|
1 | 2 | 3 | 4 | 5 | 6 | |
Amyloid | ||||||
Ala | 0.510 | 0.814 | 1.469 | 1.056 | 0.000 | 0.814 |
Asp | 0.848 | 0.848 | 1.259 | 0.000 | 0.000 | 0.606 |
Cys | 0.000 | -0.434 | -0.021 | -0.021 | 0.000 | -0.263 |
Glu | 0.639 | 0.335 | 0.135 | 0.468 | 1.294 | -0.974 |
Phe | -0.060 | -0.231 | -0.833 | -0.060 | -0.806 | -0.300 |
Gly | -0.007 | 0.596 | 1.422 | 0.000 | 0.000 | 1.009 |
His | -0.386 | 0.027 | 0.000 | 0.681 | 0.000 | 0.000 |
Ile | 0.408 | -0.137 | 1.235 | -1.225 | -1.460 | 0.580 |
Lys | 0.080 | 0.000 | 0.000 | 1.239 | 0.000 | 0.826 |
Leu | 0.310 | -0.103 | 0.231 | -0.252 | 1.056 | 0.310 |
Met | -0.291 | 0.255 | 0.668 | 0.000 | 0.000 | -0.491 |
Asn | -0.142 | 0.685 | 0.442 | -0.688 | 0.000 | 0.029 |
Pro | 0.000 | 0.000 | 0.000 | 0.000 | 0.000 | 0.000 |
Gln | 0.340 | -0.314 | -0.165 | 0.000 | 0.996 | -0.534 |
Arg | 0.734 | 0.000 | 0.000 | 0.000 | 0.000 | 0.000 |
Ser | -1.036 | 0.602 | 0.098 | 1.259 | 1.259 | -0.171 |
Thr | 0.829 | -1.089 | 0.000 | 0.175 | 1.244 | 0.083 |
Val | -0.014 | -0.071 | -1.191 | 1.355 | 0.000 | -0.071 |
Trp | -0.413 | 0.000 | -0.546 | -0.747 | 0.413 | 0.413 |
Tyr | -0.204 | -0.353 | 0.956 | -0.283 | -0.798 | -0.112 |
Non-amyloid | ||||||
Ala | 0.423 | -0.070 | 0.622 | 0.927 | 0.622 | 0.757 |
Asp | 0.214 | 0.718 | 0.306 | 0.548 | 0.414 | 0.306 |
Cys | 0.000 | 0.093 | -0.320 | 0.500 | 0.000 | 0.000 |
Glu | -0.073 | -0.206 | -0.244 | -0.021 | 0.340 | -0.874 |
Phe | -0.250 | 0.054 | -0.772 | -0.492 | -0.864 | -0.359 |
Gly | 0.710 | 0.375 | 0.879 | 0.467 | 1.528 | 0.225 |
His | -0.165 | 0.139 | 0.382 | 0.139 | 0.382 | 0.382 |
Ile | 0.280 | 0.108 | 0.280 | -0.866 | -1.122 | 0.038 |
Lys | -0.370 | 0.285 | 0.192 | 0.393 | 0.285 | 0.393 |
Leu | 0.516 | -0.031 | 0.273 | -0.423 | 0.423 | 0.011 |
Met | 0.126 | -0.178 | 0.369 | 0.778 | 0.778 | -0.378 |
Asn | -0.028 | 1.207 | -0.270 | -0.099 | 0.251 | 0.385 |
Pro | 0.397 | 0.566 | 0.397 | 0.262 | 0.262 | 0.262 |
Gln | 0.451 | 0.451 | 0.040 | 0.282 | 0.282 | -0.052 |
Arg | -0.050 | 0.604 | 0.604 | 0.300 | 0.848 | 0.192 |
Ser | -0.827 | 0.132 | 0.132 | 0.303 | 0.716 | 0.061 |
Thr | 0.117 | -0.899 | 0.530 | 0.196 | 0.942 | -0.125 |
Val | 0.402 | 0.310 | -0.681 | 0.645 | 0.310 | 0.645 |
Trp | -0.130 | 0.114 | -0.634 | 0.521 | 0.114 | -0.130 |
Tyr | -0.240 | -0.360 | 0.413 | -0.170 | -0.503 | 0.243 |