Figure 4

Example prediction. Prediction for the interaction between two ESCRT-II complex subunits: VPS25 (YJR102C) and VPS36 (YLR417W). The two proteins, their domains, and all the residue pairs in the dataset, are known to interact. Solid black lines indicate a predicted interaction, dotted lines a non-interaction; residue pairs not connected by either a solid or dotted line are not present in the dataset. (Left) SBR- ∃ _n predictions with no constraints: the predictions at the three levels are inconsistent. (Right) SBR- ∃ _n predictions with the full set of constraints: the protein- and domain-level predictions are now both consistent and correct. A further residue pair is now correctly predicted as interacting.