A comprehensive study of small non-frameshift insertions/deletions in proteins and prediction of their phenotypic effects by a machine learning method (KD4i)

Table 2 Semantic categories of the 5 physico-chemical properties: volume, hydrophobicity, charge, and polarity

Physico-chemical property	Semantic categories	Numeric categories	Real values
Volume [34]	Very small	0	60-90 Å³
	Small	1	108-117 Å³
	Medium	2	138-154 Å³
	Large	3	162-174 Å³
	Very large	4	189-228 Å³
Hydrophobicity [35]	Hydrophilic	0	−55 to −14
	Neutral	1	−10 to 13
	Hydrophobic	2	41 to 63
	Very hydrophobic	3	74 to 100
Polarity [36]	Polar	0
Polarity [36]	Apolar	1
Charge [36]	Negative	−1
Charge [36]	Neutral	0
	Positive	1

ISSN: 1471-2105