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Table 2 Semantic categories of the 5 physico-chemical properties: volume, hydrophobicity, charge, and polarity

From: A comprehensive study of small non-frameshift insertions/deletions in proteins and prediction of their phenotypic effects by a machine learning method (KD4i)

Physico-chemical property Semantic categories Numeric categories Real values
Volume [34] Very small 0 60-90 Å3
Small 1 108-117 Å3
Medium 2 138-154 Å3
Large 3 162-174 Å3
Very large 4 189-228 Å3
Hydrophobicity [35] Hydrophilic 0 −55 to −14
Neutral 1 −10 to 13
Hydrophobic 2 41 to 63
Very hydrophobic 3 74 to 100
Polarity [36] Polar 0  
Apolar 1
Charge [36] Negative −1  
Neutral 0
  Positive 1