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Table 3 Annotation of amino acids based on classified values of 4 physico-chemical properties: volume, hydrophobicity, charge, and polarity

From: A comprehensive study of small non-frameshift insertions/deletions in proteins and prediction of their phenotypic effects by a machine learning method (KD4i)

Amino Acid

Volume

Hydrophobicity

Charge

Polarity

A

1

2

0

1

C

2

2

0

1

D

2

0

−1

0

E

3

0

−1

0

F

5

3

0

1

G

1

1

0

1

H

3

1

1

0

I

4

3

0

1

K

4

0

1

0

L

4

3

0

1

M

4

3

0

1

N

2

0

0

0

P

2

0

0

1

Q

3

1

0

0

R

4

0

1

0

S

1

1

0

0

T

2

1

0

0

V

3

3

0

1

W

5

3

0

0

Y

5

2

0

0