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Table 3 Annotation of amino acids based on classified values of 4 physico-chemical properties: volume, hydrophobicity, charge, and polarity

From: A comprehensive study of small non-frameshift insertions/deletions in proteins and prediction of their phenotypic effects by a machine learning method (KD4i)

Amino Acid Volume Hydrophobicity Charge Polarity
A 1 2 0 1
C 2 2 0 1
D 2 0 −1 0
E 3 0 −1 0
F 5 3 0 1
G 1 1 0 1
H 3 1 1 0
I 4 3 0 1
K 4 0 1 0
L 4 3 0 1
M 4 3 0 1
N 2 0 0 0
P 2 0 0 1
Q 3 1 0 0
R 4 0 1 0
S 1 1 0 0
T 2 1 0 0
V 3 3 0 1
W 5 3 0 0
Y 5 2 0 0