Table 1 Perturbed pathways obtained by SPIA on FTLD-U data
From: Investigating perturbed pathway modules from gene expression data via structural equation models
Name pathway | pSize | NDE | pNDE | tA | pPERT | pGFdr | Status |
|---|---|---|---|---|---|---|---|
Glutamatergic synapse | 77 | 11 | 0.000 | -6.557 | 0.064 | 0.006 | Inhibited |
GABAergic synapse | 60 | 10 | 0.000 | 0.632 | 0.804 | 0.017 | Activated |
Calcium signaling pathway | 166 | 17 | 0.000 | 0.072 | 0.993 | 0.021 | Activated |
Amphetamine addiction | 55 | 8 | 0.001 | -2.685 | 0.457 | 0.047 | Inhibited |
Gap junction | 85 | 10 | 0.001 | 5.216 | 0.454 | 0.047 | Activated |
MAPK signaling pathway | 235 | 18 | 0.001 | -5.802 | 0.253 | 0.047 | Inhibited |
ECM-receptor interaction | 82 | 7 | 0.022 | 6.150 | 0.015 | 0.047 | Activated |