Table 5 Single node and edge differences found between MS and control groups
From: Investigating perturbed pathway modules from gene expression data via structural equation models
Path | Type | Multiple sclerosis ( MS ) | Control (C) | Difference (95% CI) | P-value | Up/down |
|---|---|---|---|---|---|---|
382 ← group | Group on node | -9.002 | -7.963 | -1.04 (-1.65; -0.43) | 0.001 | MS down-expressed |
10093 ← group | Group on node | -0.452 | 0.032 | -0.48 (-0.93; -0.04) | 0.033 | MS down-expressed |
5580 ← group | Group on node | -3.054 | -2.648 | -0.41 (-0.70; -0.11) | 0.007 | MS down-expressed |
5321 ← group | Group on node | 0.694 | 1.240 | -0.55 (-1.00;-0.09) | 0.020 | MS down-expressed |
1399 ← group | Group on node | 4.688 | 6.126 | -1.44 (-1.82;-1.05) | 0.000 | MS down-expressed |
8613 ↔ 8612 | Indirect | 0.001 | -0.002 | 0.003 (0.001;0.004) | 0.038 | MS up-associated |
23396 ← 8613 | Indirect | 0.643 | -4.981 | 5.62 (2.44; 8.81) | 0.001 | MS up-regulated |
23396 ← 5880 | Activation | 0.079 | 1.207 | -1.13 (-1.91;-0.35) | 0.005 | MS down-regulated |
23396 ← 8612 | Indirect | -6.219 | -0.945 | -5.27 (-6.62; -3.92) | 0.000 | MS down-regulated |
10093 ← 8936 | Activation | 0.576 | 0.267 | 0.31 (0.08; 0.53) | 0.007 | MS up-regulated |
5581 ← 8613 | Indirect | 0.002 | 0.953 | -0.95 (-1.41; -0.49) | 0.000 | MS down-regulated |
5581 ← 8612 | Indirect | 1.343 | 0.104 | 1.24 (0.78; 1.70) | 0.000 | MS up-regulated |
382 ← 1399 | Directed path | 0.970 | 0.144 | 0.83 (0.19; 1.46) | 0.011 | MS up-regulated |
7454 ← 5338 | Directed path | 1.070 | 0.111 | 0.96 (0.28; 1.64) | 0.006 | MS up-regulated |
5604 ← 8613 | Directed path | 0.618 | 3.133 | -2.52 (-4.64; -0.39) | 0.020 | MS down-regulated |
23396 ← 1399 | Directed path | -0.323 | -0.755 | 0.43 (0.24; 0.62) | 0.000 | MS up-regulated |