Figure 3

Network coverage by path length. The number of target genes reachable by 32 source genes (from a threshold of |r²| > 0.95) is much lesser than that reachable by 392 source genes (from a threshold of |r| > 0.95) at a path length of 4. However, using 392 source genes is not practical for experimental validation. By removing redundant source genes, we arrived at 49 source genes but at a loss of 101 target genes. By supplementing with 10 genes with high degrees (total of 59 source genes), we increased the reach by 87 target genes, giving a total of 6140 reachable target genes from 59 source genes.