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Table 1 Performance over 50 down-sampling experiments at 10X, and 20X coverage

From: PBHoney: identifying genomic variants via long-read discordance and interrupted mapping

Coverage

10x

20x

Params

"c5 e5"

"c7 e5"

"c5 e7"

"c3 e5"

"c5 e3"

"c5 e5"

"c7 e5"

"c5 e7"

"c3 e5"

"c5 e3"

TP

210

182

187

217

210

234

239

228

237

236

FP

25

0

7

55

302

1

0

1

3

46

FN

40

68

63

40

38

16

11

22

13

14

Sensitivity

84.00%

72.80%

74.80%

86.80%

84.00%

93.60%

95.60%

91.20%

94.80%

94.40%

PPV

89.36%

100.00%

96.39%

79.78%

41.02%

99.57%

100.00%

99.56%

98.75%

83.69%

  1. True Positive (TP) False Positive (FP) False Negative (FN) counts, Sensitivity, and Positive Predictive Value (PPV). PPV is the probability any given variant call is true (TP/(TP+FP)). Parameters changed are Coverage (c) and Standard-deviation Threshold (e) for spots signal processing.