Identification of putative pathogenic SNPs implied in schizophrenia-associated miRNAs

BMC Bioinformatics

Table 1 Free energy change caused by SNPs

Segment	SNP			SNP with changed free energy			SZ-SNP
	Number	Range of free energy change	Average free energy change	Number	Range of free energy change	Average free energy change	Number	Range of free energy change	Average free energy change
Terminal loop	1284	[-6.2, 5.5]	0.08	176	[-6.2, 0)	-1.1	57	[-6.2,-1.3]	-2.5
Mature miRNA	3585	[4.7, -3.4]	0.56	2310	[4.7, 0)	1.3	888	[4.7, 1.5]	2.2
Extension duplex	4065	[18.2, -10.9]	0.6	1775	[18.2, 0)	2.6	533	[18.2,2.7]	6.0

SNPs with changed free energy are those causing decrease in free energy of terminal loops and those causing increase in free energy of mature miRNAs and extension duplexes.

ISSN: 1471-2105